A comprehensive SARS-CoV-2-human protein-protein interactome network identifies pathobiology and host-targeting therapies for COVID-19

Abstract excerpt

<title>Abstract</title> <p> Physical interactions between viral and host proteins are responsible for almost all aspects of the viral life cycle and the host’s immune response. Studying viral-host protein-protein interactions is thus crucial for identifying strategies for treatment and prevention of viral infection. Here, we use high-throughput yeast two-hybrid and affinity purification followed by mass spectrom...

Topics

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• Bioinformatics and Genomic Networks
• Computational Drug Discovery Methods
• CRISPR and Genetic Engineering
• interferon and immune responses
• Mosquito-borne diseases and control
• SARS-CoV-2 and COVID-19 Research
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

0bcbc5c2-82fd-5c42-b385-c3983f2422af

DOI

10.21203/rs.3.rs-1354127/v2