Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma.

doi:10.1038/s41467-022-33718-7

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Article

Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma.

Nature communications - 8 Oct 2022

Topham James T, Tsang Erica S, Karasinska Joanna M, Metcalfe Andrew, Ali Hassan, Kalloger Steve E, Csizmok Veronika, Williamson Laura M, Titmuss Emma, Nielsen Karina, Negri Gian Luca, Spencer Miko Sandra E, Jang Gun Ho, Denroche Robert E, Wong Hui-Li, O'Kane Grainne M, Moore Richard A, Mungall Andrew J, Loree Jonathan M, Notta Faiyaz, Wilson Julie M, Bathe Oliver F, Tang Patricia A, Goodwin Rachel, Morin Gregg B, Knox Jennifer J, Gallinger Steven, Laskin Janessa, Marra Marco A, Jones Steven J M, Schaeffer David F, Renouf Daniel J

Abstract excerpt

Oncogenic KRAS mutations are absent in approximately 10% of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) and may represent a subgroup of mPDAC with therapeutic options beyond standard-of-care cytotoxic chemotherapy. While distinct gene fusions have been implicated in KRAS wildtype mPDAC, information regarding other types of mutations remain limited, and gene expression patterns associated...

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PMID: 36209277
DOI: 10.1038/s41467-022-33718-7
PMCID: PMC9547977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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