Oocyte TET3: an epigenetic modifier responsible for maternal inheritance of glucose intolerance

Abstract excerpt

In a recent paper published in Nature , Chen et al. provide a new perspective on how glucose tolerance of the offspring is affected by pregestational hyperglycaemia. 1 They showed that oocytes isolated from hyperglycemic mice transmit the impaired glucose homeostasis to the offspring via epigenetic modifications, and insufficiency of oocyte TET3 dioxygenase is indispensable for this process.

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