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Article

Age- and sex- divergent translatomic responses of the mouse retinal pigmented epithelium

3 May 2024

Abstract excerpt

Aging is the main risk factor for age-related macular degeneration (AMD), a retinal neurodegenerative disease that leads to irreversible blindness, particularly in people over 60 years old. Retinal pigmented epithelium (RPE) atrophy is an AMD hallmark. Genome-wide chromatin accessibility, DNA methylation, and gene expression studies of AMD and control RPE demonstrate epigenomic/transcriptomic changes occur during...

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PMID: 38723422
DOI: 10.1016/j.neurobiolaging.2024.04.012

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