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Article

Unravelling genetic causality of haematopoiesis on bone metabolism in human.

European journal of endocrinology - 1 Dec 2022

Ho Shun-Cheong, Li Gloria Hoi-Yee, Leung Anskar Yu-Hung, Tan Kathryn C B, Cheung Ching-Lung

Abstract excerpt

Objective: Haematopoiesis was shown to regulate bone metabolism in in vivo studies. However, whether haematopoiesis has causal effects on bone health has never been investigated in humans. We aimed to evaluate the causal relationships of blood traits with bone mineral density (BMD) and fracture. Design and methods: Using two-sample Mendelian randomization, causal relationship of 29 blood traits with estimated BMD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36201175
DOI: 10.1530/EJE-22-0526

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