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Article

Update on hepatitis C virus resistance to direct-acting antiviral agents.

Antiviral research - 1 Aug 2014

Poveda Eva, Wyles David L, Mena Alvaro, Pedreira José D, Castro-Iglesias Angeles, Cachay Edward

Abstract excerpt

Resistance to direct-acting antiviral (DAA) agents against hepatitis C virus (HCV) infection is driven by the selection of mutations at different positions in the NS3 protease, NS5B polymerase and NS5A proteins. With the exception of NS5B nucleos(t)ide inhibitors, most DAAs possess a low genetic barrier to resistance, with significant cross-resistance between compounds belonging to the same family. However, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24911972
DOI: 10.1016/j.antiviral.2014.05.015

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