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Article

Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Dec 2012

Dar-Nimrod Ilan, Chapman Benjamin P, Franks Peter, Robbins John, Porsteinsson Anton, Mapstone Mark, Duberstein Paul R

Abstract excerpt

OBJECTIVES: We tested the hypothesis that neuroticism moderates the association between APOE (apolipoprotein E) genotype and two major outcomes, cognitive function and Alzheimer disease. We also explored whether other personality dimensions (extraversion, openness to experience, agreeableness, and conscientiousness) moderate the associations of APOE with these outcomes. DESIGN: Primary analyses of existing...

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Source

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Identifiers

PMID: 23079898
DOI: 10.1097/JGP.0b013e318267016b
PMCID: PMC4184145

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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