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CD163 and CD206 expression define distinct macrophage subsets involved in active ANCA-associated glomerulonephritis

29 Sept 2022

Abstract excerpt

Macrophages are key players in the immunopathology of anti-neutrophil cytoplasmic antibody (ANCA) mediated-vasculitis (AAV) with glomerulonephritis (ANCA GN). Different macrophage phenotypes are expected to play distinct roles in ANCA GN. Macrophages expressing CD163 and CD206 are found in lesions associated with ANCA GN. Hence, we aimed to investigate the clinicopathological significance of CD206 and CD163 in...

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PMID: 36183584
DOI: 10.1016/j.jaut.2022.102914

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