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Identification of DNA methylation-regulated genes as potential biomarkers for coronary heart disease via machine learning in the Framingham Heart Study

30 Sept 2022

Abstract excerpt

BACKGROUND: DNA methylation-regulated genes have been demonstrated as the crucial participants in the occurrence of coronary heart disease (CHD). The machine learning based on DNA methylation-regulated genes has tremendous potential for mining non-invasive predictive biomarkers and exploring underlying new mechanisms of CHD. RESULTS: First, the 2085 age-gender-matched individuals in Framingham Heart Study (FHS)...

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PMID: 36180886
DOI: 10.1186/s13148-022-01343-2

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