Article
CYP2D6 and CYP2C8 pharmacogenetics and pharmacological interactions to predict imatinib plasmatic exposure in GIST patients.
British journal of clinical pharmacology - 1 Mar 2023
Dalle Fratte Chiara, Gagno Sara, Roncato Rossana, Polesel Jerry, Zanchetta Martina, Buzzo Mauro, Posocco Bianca, De Mattia Elena, Borsatti Rachele, Puglisi Fabio, Foltran Luisa, Guardascione Michela, Buonadonna Angela, Cecchin Erika, Toffoli Giuseppe
Abstract excerpt
AIMS: Patients on treatment with oral fixed dose imatinib are frequently under- or overexposed to the drug. We investigated the association between the gene activity score (GAS) of imatinib-metabolizing cytochromes (CYP3A4, CYP3A5, CYP2D6, CYP2C9, CYP2C19, CYP2C8) and imatinib and nor-imatinib exposure. We also investigated the impact of concurrent drug-drug-interactions (DDIs) on the association between GAS and...
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