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Article

Genetic Polymorphisms Contribute to the Individual Variations of Imatinib Mesylate Plasma Levels and Adverse Reactions in Chinese GIST Patients.

International journal of molecular sciences - 13 Mar 2017

Liu Jing, Chen Zhiyu, Chen Hanmei, Hou Yingyong, Lu Weiqi, He Junyi, Tong Hanxing, Zhou Yuhong, Cai Weimin

Abstract excerpt

Imatinib mesylate (IM) has dramatically improved the outcomes of gastrointestinal stromal tumor (GIST) patients. However, the clinical responses of IM may considerably vary among single individuals. This study aimed to investigate the influences of genetic polymorphisms of drug-metabolizing enzyme (CYP3A4), transporters (ABCB1, ABCG2), and nuclear receptor (Pregnane X Receptor (PXR, encoded by NR1I2)) on IM...

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Share to Antineoplastic Agents
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Share to Cytochrome P-450 CYP3A

Share to Gastrointestinal Stromal Tumors

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Source

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Identifiers

PMID: 28335376
DOI: 10.3390/ijms18030603
PMCID: PMC5372619

Genes

ABCB1
ABCG2

Provenance

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