Article
Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib.
Clinical pharmacology and therapeutics - 1 Aug 2006
Gardner Erin R, Burger Herman, van Schaik Ron H, van Oosterom Allan T, de Bruijn Ernst A, Guetens Gunther, Prenen Hans, de Jong Floris A, Baker Sharyn D, Bates Susan E, Figg William D, Verweij Jaap, Sparreboom Alex, Nooter Kees
Abstract excerpt
OBJECTIVE: Our objective was to explore the relationships between imatinib pharmacokinetics and 9 allelic variants in 7 genes coding for adenosine triphosphate-binding cassette transporters (ABCB1 and ABCG2) and enzymes (cytochrome P450 [CYP] 2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5) of putative relevance for imatinib. METHODS: Imatinib transport in vitro was studied by use of human embryonic kidney 293 cells...
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