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Article

CYP2C8 Genotype Significantly Alters Imatinib Metabolism in Chronic Myeloid Leukaemia Patients.

Clinical pharmacokinetics - 1 Aug 2017

Barratt Daniel T, Cox Hannah K, Menelaou Andrew, Yeung David T, White Deborah L, Hughes Timothy P, Somogyi Andrew A

Abstract excerpt

OBJECTIVE: The aims of this study were to determine the effects of the CYP2C8*3 and *4 polymorphisms on imatinib metabolism and plasma imatinib concentrations in chronic myeloid leukaemia (CML) patients. METHODS: We genotyped 210 CML patients from the TIDELII trial receiving imatinib 400-800 mg/day for CYP2C8*3 (rs11572080, rs10509681) and *4 (rs1058930). Steady-state trough total plasma N-desmethyl imatinib...

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Share to Aged, 80 and over
Share to Clinical Trials, Phase II as Topic
Share to Cytochrome P-450 CYP2C8
Share to Imatinib Mesylate
Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Share to Pharmacogenetics
Share to Protein Kinase Inhibitors
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Identifiers

PMID: 27995529
DOI: 10.1007/s40262-016-0494-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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