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Genetic and Non-genetic Correlates of Imatinib Pharmacokinetics and Side Effects of Imatinib in Palestinian Patients with Chronic Myeloid Leukemia.

Biochemical genetics - 1 Apr 2026

Adawi Deema Hilmi, Al-Barghouthi Ahmad, Fredj Nadia Ben, Lubada Mustafa, Njjar Dania Osama, Ruzaygat Mahmoud, Hallak Hussein, Aouam Karim

Abstract excerpt

Chronic myeloid leukemia (CML) treatment with imatinib mesylate often faces challenges due to inter-patient variability in drug response and adverse effects. Genetic polymorphisms in enzymes involved in imatinib metabolism, such as CYP2C8 and CYP3A4, may contribute to this variability. This study aimed to investigate the distribution of CYP2C8*3, CYP2C8*4, and CYP3A4*22 among CML patients and evaluate their...

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Antineoplastic Agents
Arabs
Cross-Sectional Studies
Cytochrome P-450 CYP2C8
Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Imatinib Mesylate

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Identifiers

PMID: 40355686
DOI: 10.1007/s10528-025-11130-2

Genes

CYP2C8
CYP3A4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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