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Article

Association of ABCG2 polymorphism with clinical efficacy of imatinib in patients with gastrointestinal stromal tumor.

Cancer chemotherapy and pharmacology - 1 Jan 2015

Koo Dong-Hoe, Ryu Min-Hee, Ryoo Baek-Yeol, Beck Mo Youl, Na Young-Soon, Shin Jae-Gook, Lee Sang Seop, Kim Eun-Young, Kang Yoon-Koo

Abstract excerpt

PURPOSE: Imatinib is a substrate of drug transporters and metabolizing enzymes, including members of the cytochrome P450 (CYP) system. Differences in imatinib pharmacokinetics among individuals might be influenced by genetic polymorphisms and be associated with variable clinical imatinib efficacy. This study sought to test how genetic polymorphisms can affect the clinical efficacy of imatinib and its blood levels...

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Source

Identifiers

PMID: 25417047
DOI: 10.1007/s00280-014-2630-6

Genes

ABCG2
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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