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Article

Influence of Cytochrome P450, ABC and SLC Gene Polymorphisms on Imatinib Therapy Outcome of Patients with Gastrointestinal Stromal Tumours (GIST).

Folia biologica - 1 Jan 2017

Wasielewski K, Wasag B, Wozniak A, Pikiel J, Kowalik A, Osuch C, Bylina E, Siedlecki J A, Rutkowski P, Limon J

Abstract excerpt

The efficacy of imatinib-based therapy depends on the proteins involved in its metabolism and transportation. Therefore, the aim of our study was to investigate the possible correlation of selected P450, ABC and SLC polymorphic variants and the outcome of imatinib therapy. A total of 101 patients with advanced, KIT/PDGFRA(+) GIST treated with imatinib were enrolled to the study. DNA was extracted from peripheral...

Read the complete abstract on PubMed

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Share to Antineoplastic Agents
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Gastrointestinal Stromal Tumors

Share to Polymerase Chain Reaction

Share to Polymorphism, Restriction Fragment Length

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 28557709
DOI: 10.14712/fb2017063020078

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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