Article
Manipulation of tissue factor-mediated basal PAR-2 signalling on macrophages determines sensitivity for IFNγ responsiveness and significantly modifies the phenotype of murine DTH.
Frontiers in immunology - 1 Jan 2022
Wilkinson Hannah, Leonard Hugh, Robson Michael G, Smith Richard, Tam ElLi, McVey John H, Kirckhofer Daniel, Chen Daxin, Dorling Anthony
Abstract excerpt
Background: Tissue factor (TF) generates proteases that can signal through PAR-1 and PAR-2. We have previously demonstrated PAR-1 signalling primes innate myeloid cells to be exquisitely sensitive to interferon-gamma (IFNγ). In this work we explored how TF mediated PAR-2 signalling modulated responsiveness to IFNγ and investigated the interplay between PAR-1/-2 signalling on macrophages. Methodology: We...
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