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Article

Reciprocal positive regulation between BRD4 and YAP in GNAQ-mutant uveal melanoma cells confers sensitivity to BET inhibitors.

Pharmacological research - 1 Oct 2022

Zhang Gui-Ming, Huang Si-Si, Ye Lin-Xuan, Liu Xiao-Lian, Shi Wen-Hui, Ren Zhong-Lu, Zhou Run-Hua, Zhang Jia-Jie, Pan Jing-Xuan, Liu Shu-Wen, Yu Le, Li Yi-Lei

Abstract excerpt

Uveal melanoma (UM) is the most common intraocular cancer in adults. UMs are usually initiated by a mutation in GNAQ or GNA11 (encoding Gq or G11, respectively), unlike cutaneous melanomas (CMs), which usually carry a BRAF or NRAS mutation. Currently, there are no clinically effective targeted therapies for UM carrying Gq/11 mutations. Here, we identified a causal link between Gq activating mutations and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36162600
DOI: 10.1016/j.phrs.2022.106464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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