Article
Redox status regulates autophagy in thymic stromal cells and promotes T cell tolerance.
Proceedings of the National Academy of Sciences of the United States of America - 4 Oct 2022
Semwal Manpreet K, Hester Allison K, Xiao Yangming, Udeaja Chioma, Cepeda Sergio, Verschelde John S, Jones Nicholas, Wedemeyer Sarah A, Emtage Simon, Wimberly Kymberly, Griffith Ann V
Abstract excerpt
Thymic stromal cells (TSCs) are critical regulators of T cell tolerance, but their basic biology has remained under-characterized because they are relatively rare and difficult to isolate. Recent work has revealed that constitutive autophagy in TSCs is required for self-antigen presentation and central T cell tolerance induction; however, the mechanisms regulating constitutive autophagy in TSCs are not well...
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