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Article

Effect of Lenvatinib treatment on the cell cycle and microRNA profile in hepatocellular carcinoma cells

3 Aug 2022

Abstract excerpt

Lenvatinib is a tyrosine kinase receptor inhibitor used to treat unresectable hepatocellular carcinoma (HCC). In this study, we investigated the antitumor effects of Lenvatinib treatment on HCC cell lines. Proliferation was examined in four HCC cell lines (HuH‑7, Hep3B, Li‑7, and PLC/PRF/5) using Cell Counting Kit‑8 assays. Xenograft mouse models were used to assess the effects of Lenvatinib in vivo. Cell cycle,...

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PMID: 36158319
DOI: 10.3892/br.2022.1561

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