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Hydrazone chemistry-mediated CRISPR/Cas12a system for bacterial analysis

26 Sept 2022

Abstract excerpt

In this study, a hydrazone chemistry-mediated clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated protein 12a (Cas12a) system has been proposed for the fist time and constructed. In our system, hydrazone chemistry is designed and employed to accelerate the formation of a whole activation strand by taking advantage of the proximity effect induced by complementary base pairing, thus...

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PMID: 36156138
DOI: 10.1093/nar/gkac809

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