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Article

Theodore E. Woodward award. The evolution of obesity: insights from the mid-Miocene.

Transactions of the American Clinical and Climatological Association - 1 Jan 2010

Johnson Richard J, Andrews Peter, Benner Steven A, Oliver William

Abstract excerpt

All humans are double knockouts. Humans lack the ability to synthesize vitamin C due to a mutation in L-gulono-lactone oxidase that occurred during the late Eocene, and humans have higher serum uric acid levels due to a mutation in uricase that occurred in the mid Miocene. In this paper we review the hypothesis that these mutations have in common the induction of oxidative stress that may have had prosurvival...

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Identifiers

PMID: 20697570
PMCID: PMC2917125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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