Article
Comparison between Three Different Techniques for the Detection of EGFR Mutations in Liquid Biopsies of Patients with Advanced Stage Lung Adenocarcinoma.
International journal of molecular sciences - 29 Mar 2023
Casula Milena, Pisano Marina, Paliogiannis Panagiotis, Colombino Maria, Sini Maria Cristina, Zinellu Angelo, Santeufemia Davide, Manca Antonella, Casula Stefania, Tore Silvia, Lobrano Renato, Sardinian Lung Cancer Study Group, Cossu Antonio, Palmieri Giuseppe
Abstract excerpt
Oncogenic mutations in the EGFR gene are targets of tyrosine kinase inhibitors (TKIs) in lung adenocarcinoma (LC) patients, and their search is mandatory to make decisions on treatment strategies. Liquid biopsy of circulating tumour DNA (ctDNA) is increasingly used to detect EGFR mutations, including main activating alterations (exon 19 deletions and exon 21 L858R mutation) and T790M mutation, which is the most...
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