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Article

Functional characterization of cAMP signaling of variant porcine MC1R alleles in PK15 cells.

Animal genetics - 1 Jun 2022

Lan Jin, Wang Min, Qin Ke, Liu Xiaofeng, Shi Xuan, Sun Guanjie, Liu Xiaohong, Chen Yaosheng, He Zuyong

Abstract excerpt

The melanocortin 1 receptor (MC1R), encoded by the classical extension (E) coat color locus, is expressed on the surface of melanocytes and plays a critical role in switching melanin synthesis from pheomelanin (red/yellow) to eumelanin (black/brown). Different MC1R alleles associated with various coat color patterns in pigs have been identified over the past decades. However, functional analysis of variant...

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PMID: 35292981
DOI: 10.1111/age.13189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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