Article
A frameshift mutation in MC1R and a high frequency of somatic reversions cause black spotting in pigs.
Genetics - 1 Jun 2001
Kijas J M, Moller M, Plastow G, Andersson L
Abstract excerpt
Black spotting on a red or white background in pigs is determined by the E(P) allele at the MC1R/Extension locus. A previous comparison of partial MC1R sequences revealed that E(P) shares a missense mutation (D121N) with the E(D2) allele for dominant black color. Sequence analysis of the entire coding region now reveals a second mutation in the form of a 2-bp insertion at codon 23 (nt67insCC). This mutation...
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