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Z-DNA binding protein 1 promotes heatstroke-induced cell death

5 May 2022

Abstract excerpt

Heatstroke is a heat stress-induced, life-threatening condition associated with circulatory failure and multiple organ dysfunctions. If global warming continues, heatstroke might become a more prominent cause of mortality worldwide, but its pathogenic mechanism is not well understood. We found that Z-DNA binding protein 1 (ZBP1), a Z-nucleic acid receptor, mediated heatstroke by triggering receptor-interacting...

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PMID: 35511979
DOI: 10.1126/science.abg5251

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