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Article

Germline variants in cancer-predisposing genes in pancreatic cancer patients with a family history of cancer.

Japanese journal of clinical oncology - 6 Oct 2022

Terashima Takeshi, Morizane Chigusa, Ushiama Mineko, Shiba Satoshi, Takahashi Hideaki, Ikeda Masafumi, Mizuno Nobumasa, Tsuji Kunihiro, Yasui Kohichiroh, Azemoto Nobuaki, Satake Hironaga, Nomura Shogo, Yachida Shinichi, Sugano Kokichi, Furuse Junji

Abstract excerpt

BACKGROUND: Our phase II trial (FABRIC study) failed to verify the efficacy of gemcitabine plus oxaliplatin (GEMOX) in patients with pancreatic ductal adenocarcinoma (PDAC) with a familial or personal history of pancreatic, breast, ovarian or prostate cancer, which suggested that a family and personal history may be insufficient to determine response to platinum-based chemotherapy. METHODS: This ancillary...

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Identifiers

PMID: 36135357
DOI: 10.1093/jjco/hyac110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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