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Mitochondrial Autoantibodies and the Role of Apoptosis in Pemphigus Vulgaris

25 Aug 2022

Abstract excerpt

Pemphigus vulgaris (PV) is an IgG autoantibody-mediated, potentially fatal mucocutaneous disease manifested by progressive non-healing erosions and blisters. Beyond acting to inhibit adhesion molecules, PVIgGs elicit a unique process of programmed cell death and detachment of epidermal keratinocytes termed apoptolysis. Mitochondrial damage by antimitochondrial antibodies (AMA) has proven to be a critical link in...

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PMID: 36134951
DOI: 10.3390/antib11030055

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