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Article

Gene set enrichment analysis of pathophysiological pathways highlights oxidative stress in psychosis.

Molecular psychiatry - 1 Dec 2022

Pistis Giorgio, Vázquez-Bourgon Javier, Fournier Margot, Jenni Raoul, Cleusix Martine, Papiol Sergi, Smart Sophie E, Pardiñas Antonio F, Walters James T R, MacCabe James H, Kutalik Zoltán, Conus Philippe, Crespo-Facorro Benedicto, Q Do Kim

Abstract excerpt

Polygenic risk prediction remains an important aim of genetic association studies. Currently, the predictive power of schizophrenia polygenic risk scores (PRSs) is not large enough to allow highly accurate discrimination between cases and controls and thus is not adequate for clinical integration. Since PRSs are rarely used to reveal biological functions or to validate candidate pathways, to fill this gap, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36131045
DOI: 10.1038/s41380-022-01779-1
PMCID: PMC9763118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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