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Article

APOE Alleles With Tau and Aβ Pathology in Patients With Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex in the Kii Peninsula.

Neurology - 29 Nov 2022

Sasaki Ryogen, Morimoto Satoru, Ozawa Fumiko, Okano Hideyuki, Yoshida Mari, Ishiura Hiroyuki, Tsuji Shoji, Kuzuhara Shigeki, Kokubo Yasumasa

Abstract excerpt

BACKGROUND AND OBJECTIVES: To examine the association of the APOE ε4 and ε2 alleles with the pathologic features of patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex cases in the Kii peninsula of Japan (Kii ALS/PDC). METHODS: We analyzed APOE variants in 18 autopsy patients with ALS/PDC, consisting of 9, 8, and 1 patient with PDC, ALS, and PDC followed by ALS, respectively. Moreover,...

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Identifiers

PMID: 36130843
DOI: 10.1212/WNL.0000000000201156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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