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Article

An immigrant family with Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Feb 2022

Kokubo Yasumasa, Morimoto Satoru, Sasaki Ryogen, Hasegawa Masato, Ishiura Hiroyuki, Tsuji Shoji, Yoshida Mari, Yamazoe Naohisa, Miyazaki Mitsukazu, Kuzuhara Shigeki

Abstract excerpt

OBJECTIVES: Amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) is a unique endemic on Guam island of the USA, the Kii Peninsula of Japan, and Papua state of Indonesia. The pathomechanism of ALS/PDC remains to be solved, although interaction between some environmental factors and genetic background is plausible. This is the first autopsy-proven immigrant family of ALS/PDC of the Kii Peninsula....

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PMID: 34779964
DOI: 10.1007/s10072-021-05737-7

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