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Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice

13 Sept 2023

Abstract excerpt

A recently emerged sub-lineage of Omicron, BA.5, together with BA.4, caused a fifth wave of coronavirus disease (COVID-19) in South Africa and subsequently emerged as a predominant strain globally due to its high transmissibility. The lethality of BA.5 infection has not been studied in an acute hACE2 transgenic (hACE2.Tg) mouse model. Here, we investigated tissue-tropism and immuno-pathology induced by BA.5...

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PMID: 37704701
DOI: 10.1038/s42003-023-05263-6

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