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Article

Middle East Respiratory Syndrome Coronavirus Gene 5 Modulates Pathogenesis in Mice.

Journal of virology - 13 Jan 2021

Gutierrez-Alvarez Javier, Wang Li, Fernandez-Delgado Raul, Li Kun, McCray Paul B, Perlman Stanley, Sola Isabel, Zuñiga Sonia, Enjuanes Luis

Abstract excerpt

Middle East respiratory syndrome coronavirus (MERS-CoV) causes a highly lethal pneumonia that emerged in 2012. There is limited information on MERS-CoV pathogenesis, as data from patients are scarce and the generation of animal models reproducing MERS clinical manifestations has been challenging. Human dipeptidyl peptidase 4 knock-in (hDPP4-KI) mice and a mouse-adapted MERS-CoV strain (MERSMA-6-1-2) were recently...

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Identifiers

PMID: 33144319
DOI: 10.1128/JVI.01172-20
PMCID: PMC7925085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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