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Article

Loss of Protein Stability and Function Caused by P228L Variation in NADPH-Cytochrome P450 Reductase Linked to Lower Testosterone Levels.

International journal of molecular sciences - 4 Sept 2022

Rojas Velazquez Maria Natalia, Noebauer Mathias, Pandey Amit V

Abstract excerpt

Cytochrome P450 oxidoreductase (POR) is the redox partner of steroid and drug-metabolising cytochromes P450 located in the endoplasmic reticulum. Mutations in POR cause a broad range of metabolic disorders. The POR variant rs17853284 (P228L), identified by genome sequencing, has been linked to lower testosterone levels and reduced P450 activities. We expressed the POR wild type and the P228L variant in bacteria,...

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Identifiers

PMID: 36077536
DOI: 10.3390/ijms231710141
PMCID: PMC9456303

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