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Article

Polymorphisms in the Genes Coding for TLRs, NLRs and RLRs Are Associated with Clinical Parameters of Patients with Acute Myeloid Leukemia.

International journal of molecular sciences - 24 Aug 2022

Wicherska-Pawłowska Katarzyna, Bogunia-Kubik Katarzyna, Kuszczak Bartłomiej, Łacina Piotr, Dratwa Marta, Jaźwiec Bożena, Wróbel Tomasz, Rybka Justyna

Abstract excerpt

Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-I-like receptors (RLRs) are major elements of the innate immune system that recognize pathogen-associated molecular patterns. Single-nucleotide polymorphisms (SNPs) in the TLR, NLR, and RLR genes may lead to an imbalance in the production of pro- and anti-inflammatory cytokines, changes in susceptibility to infections, the development of diseases, and...

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Identifiers

PMID: 36076988
DOI: 10.3390/ijms23179593
PMCID: PMC9455872

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