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Identification of DDX5 as an indispensable activator of the glucocorticoid receptor in adipocyte differentiation

7 Sept 2022

Abstract excerpt

The expression of CCAAT/enhancer-binding protein (C/EBP) family members and peroxisome proliferator-activated receptor γ (PPAR γ) is essential for the differentiation of pre-adipocyte 3T3-L1 cells into mature adipocytes induced by a combined stimulation with dexamethasone, 3-isobutyl-1-methylxanthine and insulin (DMI). We herein demonstrated that the RNA helicase DDX5, the expression of which was induced by DMI,...

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PMID: 36071319
DOI: 10.1111/febs.16618

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