Article
Prevalence and detection of actionable BRAF V600 and NRAS Q61 mutations in malignant peripheral nerve sheath tumor by droplet digital PCR.
Human pathology - 1 Nov 2022
Kao Erica Y, Wakeman Kristina M, Wu Yu, Gross John M, Chen Eleanor Y, Ricciotti Robert W, Liu Yajuan J, Mantilla Jose G
Abstract excerpt
Malignant peripheral nerve sheath tumors ( MPNSTs) are aggressive tumors with poor prognosis that do not typically respond well to standard chemotherapy. Recently, point mutations involving BRAF V600E have been demonstrated in a subset of MPNST, offering the possibility of targeted treatment. However, the reported prevalence of these alterations is variable. Mutations involving NRAS, which is also involved in the...
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