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Article

Detection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis using aneuploidy and mutation identification in plasma.

eLife - 4 Mar 2022

Mattox Austin K, Douville Christopher, Silliman Natalie, Ptak Janine, Dobbyn Lisa, Schaefer Joy, Popoli Maria, Blair Cherie, Judge Kathy, Pollard Kai, Pratilas Christine, Blakeley Jaishri, Rodriguez Fausto, Papadopoulos Nickolas, Belzberg Allan, Bettegowda Chetan

Abstract excerpt

Malignant peripheral nerve sheath tumors (MPNST) are the deadliest cancer that arises in individuals diagnosed with neurofibromatosis and account for nearly 5% of the 15,000 soft tissue sarcomas diagnosed in the United States each year. Comprised of neoplastic Schwann cells, primary risk factors for developing MPNST include existing plexiform neurofibromas (PN), prior radiotherapy treatment, and expansive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35244537
DOI: 10.7554/eLife.74238
PMCID: PMC9094745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Detection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis using aneuploidy and mutation identification in plasma.PMID 35244537Read ↗

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