Article
Droplet Digital PCR (ddPCR) as a Novel Technology in Detecting CTNNB1 Mutations in Desmoid Fibromatosis.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2000
Gandhi Jatin, Kao Erica, Wu Yu, Mantilla Jose G, Ricciotti Robert W, Bandhlish Anshu, Liu Yajuan J, Chen Eleanor Y
Abstract excerpt
Desmoid fibromatosis (DF) is a locally aggressive soft tissue neoplasm with frequent recurrences. DF is characterized by alterations in the Wnt/β-catenin pathway, with the majority showing sporadic mutations in CTNNB1 , whereas others have germline mutations in APC . Immunohistochemical staining for β-catenin is often difficult to interpret and can be negative in up to 30% of cases. Prior studies have shown that...
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