Article
FMRP-related retinal phenotypes: Evidence of glutamate-glutamine metabolic cycle impairment.
Experimental eye research - 1 Nov 2022
Ardourel Maryvonne, Pâris Arnaud, Felgerolle Chloé, Lesne Fabien, Ranchon-Cole Isabelle, Briault Sylvain, Perche Olivier
Abstract excerpt
FMRP, the fragile X mental retardation protein coded by the FMR1 gene, is an RNA-binding protein that assists transport, stabilization and translational regulation of specific synaptic mRNAs. Its expression has been found in multiple cell types of central nervous system (CNS) including glial cells where its involvement in glutamate neurotransmitter homeostasis have been shown. Indeed, glutamate homeostasis...
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