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Article

The battle of the sexes in humans is highly polygenic.

Proceedings of the National Academy of Sciences of the United States of America - 24 Sept 2024

Cole Jared M, Scott Carly B, Johnson Mackenzie M, Golightly Peter R, Carlson Jedidiah, Ming Matthew J, Harpak Arbel, Kirkpatrick Mark

Abstract excerpt

Sex-differential selection (SDS), which occurs when the fitness effects of alleles differ between males and females, can have profound impacts on the maintenance of genetic variation, disease risk, and other key aspects of natural populations. Because the sexes mix their autosomal genomes each generation, quantifying SDS is not possible using conventional population genetic approaches. Here, we introduce a method...

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Identifiers

PMID: 39302970
DOI: 10.1073/pnas.2412315121
PMCID: PMC11441502

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