Article
The absence of the queuosine tRNA modification leads to pleiotropic phenotypes revealing perturbations of metal and oxidative stress homeostasis in Escherichia coli K12.
Metallomics : integrated biometal science - 24 Sept 2022
Pollo-Oliveira Leticia, Davis Nick K, Hossain Intekhab, Ho Peiying, Yuan Yifeng, Salguero García Pedro, Pereira Cécile, Byrne Shane R, Leng Jiapeng, Sze Melody, Blaby-Haas Crysten E, Sekowska Agnieszka, Montoya Alvaro, Begley Thomas, Danchin Antoine, Aalberts Daniel P, Angerhofer Alexander, Hunt John, Conesa Ana, Dedon Peter C, de Crécy-Lagard Valérie
Abstract excerpt
Queuosine (Q) is a conserved hypermodification of the wobble base of tRNA containing GUN anticodons but the physiological consequences of Q deficiency are poorly understood in bacteria. This work combines transcriptomic, proteomic and physiological studies to characterize a Q-deficient Escherichia coli K12 MG1655 mutant. The absence of Q led to an increased resistance to nickel and cobalt, and to an increased...
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