Article
Phenotypic profile linked to inhibition of the major Zn influx system in Salmonella enterica: proteomics and ionomics investigations.
Molecular bioSystems - 1 Mar 2011
Ciavardelli Domenico, Ammendola Serena, Ronci Maurizio, Consalvo Ada, Marzano Valeria, Lipoma Mario, Sacchetta Paolo, Federici Giorgio, Di Ilio Carmine, Battistoni Andrea, Urbani Andrea
Abstract excerpt
Zinc is required for a wide variety of cellular functions and plays a key role in bacterial metabolism and virulence. However, Zn can also be toxic and, therefore, its influx is tightly regulated. The high affinity zinc uptake transporter ZnuABC is the main Zn influx system in Salmonella enterica under conditions of Zn starvation. It has been shown that deletion of the gene encoding for its periplasmic subunit...
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