Article
Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression.
The Journal of experimental medicine - 7 Nov 2022
Shemesh Avishai, Su Yapeng, Calabrese Daniel R, Chen Daniel, Arakawa-Hoyt Janice, Roybal Kole T, Heath James R, Greenland John R, Lanier Lewis L
Abstract excerpt
Human adaptive-like natural killer (NK) cells express low levels of FcεRIγ (FcRγ-/low) and are reported to accumulate during COVID-19 infection; however, the mechanism underlying and regulating FcRγ expression in NK cells has yet to be fully defined. We observed lower FcRγ protein expression in NK cell subsets from lung transplant patients during rapamycin treatment, suggesting a link with reduced mTOR activity....
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