Article

Natural killer cell division regulates FcεRIγ expression downstream of mTOR activity

2021-08-05

Abstract excerpt

The expansion of human FcεRIγ -/low (FcRγ -/low ) natural killer (NK) cells accrues during viral infections; however, the molecular mechanisms regulating FcRγ expression is not well defined and can have implication for host protection and NK cell immunotherapy. Our analysis of NK cell subsets in lung transplant patients during rapamycin treatment revealed significantly lower FcRγ levels in the NK cell population...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: da25288c-9939-5aa0-9749-b5082f5c3474
DOI: 10.1101/2021.08.03.454985

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Natural killer cell division regulates FcεRIγ expression downstream of mTOR activityDOI 10.1101/2021.08.03.454985Read

Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression.Semantic proximity Read

Human RORγt+CD34+ Cells Are Lineage-Specified Progenitors of Group 3 RORγt+ Innate Lymphoid CellsSemantic proximity Read

A novel subset of NK cells expressing high levels of inhibitory FcgammaRIIB modulating antibody-dependent function.Semantic proximity Read

Cutting Edge: Antibody-Dependent Memory-like NK Cells Distinguished by FcRγ DeficiencySemantic proximity Read

Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patientsSemantic proximity Read

Phosphoinositide-3-Kinase Signaling in Human Natural Killer Cells: New Insights from Primary Immunodeficiency.Semantic proximity Read

TGF-β and IL-15 Synergize through MAPK Pathways to Drive the Conversion of Human NK Cells to an Innate Lymphoid Cell 1-like Phenotype.Semantic proximity Read

FcεRIγ-negative NK cells persist in vivo and enhance efficacy of therapeutic monoclonal antibodies in multiple myelomaSemantic proximity Read

FcRγ Gene Editing Reprograms Conventional NK Cells to Display Key Features of Adaptive Human NK CellsSemantic proximity Read

Asymptomatic CMV infections in long-term renal transplant recipients are associated with the loss of FcRγ from LIR-1+ NK cells.Semantic proximity Read

Mutations in PI3K110δ cause impaired natural killer cell function partially rescued by rapamycin treatment.Semantic proximity Read

CXCR6+ and NKG2C+ Natural Killer Cells Are Distinct With Unique Phenotypic and Functional Attributes Following Bone Marrow Transplantation.Semantic proximity Read