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Thyroid hormone T4 mitigates traumatic brain injury in mice by dynamically remodeling cell type specific genes, pathways, and networks in hippocampus and frontal cortex

14 Jul 2024

Abstract excerpt

The complex pathology of mild traumatic brain injury (mTBI) is a main contributor to the difficulties in achieving a successful therapeutic regimen. Thyroxine (T4) administration has been shown to prevent the cognitive impairments induced by mTBI in mice but the mechanism is poorly understood. To understand the underlying mechanism, we carried out a single cell transcriptomic study to investigate the...

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Neuroinflammation and Neurodegeneration Mechanisms
S100 Proteins and Annexins
Traumatic Brain Injury and Neurovascular Disturbances

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39004380
DOI: 10.1016/j.bbadis.2024.167344

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