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Article

Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury

20 Jul 2017

Abstract excerpt

The underlying molecular mechanisms of how dysregulated microRNAs (miRNAs) cause neurodegeneration after traumatic brain injury (TBI) remain elusive. Here we analyzed the biological roles of approximately 600 genes - we previously found these dysregulated in dying and surviving rat hippocampal neurons - that are targeted by ten TBI-altered miRNAs. Bioinformatic analysis suggests that neurodegeneration results...

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PMID: 28751711
DOI: 10.1038/s41598-017-06341-6

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