Article

Construction of miRNA-mRNA Regulatory Network Based on Differentially Expressed Genes in Traumatic Brain Injury Rats with Antidepressant Treatment

2025-09-11

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold>Traumatic brain injury (TBI) is a complex pathology caused by external forces that leads to brain dysfunction, mental disorders, and other complications. Currently, there are no specific drugs for treating TBI-induced mental disorders, and conventional antidepressants fail to significantly improve patient outcomes. MicroRNAs (miRNAs) play crucial roles in brain d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b8612f64-b5d8-51a9-ad75-470c3281c73e
DOI: 10.21203/rs.3.rs-7569661/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Construction of miRNA-mRNA Regulatory Network Based on Differentially Expressed Genes in Traumatic Brain Injury Rats with Antidepressant TreatmentDOI 10.21203/rs.3.rs-7569661/v1Read

MicroRNAs: The New Challenge for Traumatic Brain Injury DiagnosisSemantic proximity Read

miRNA Dysregulation in Traumatic Brain Injury and Epilepsy: A Systematic Review to Identify Putative Biomarkers for Post-Traumatic EpilepsySemantic proximity Read

Systematic Analysis of tRNA-Derived Small RNAs Reveals Effects of Xuefu-Zhuyu Decoction on Hippocampus of Rats after Traumatic Brain InjurySemantic proximity Read

Analysis of miRNA Expression Profiles in Traumatic Brain Injury (TBI) and Their Correlation with Survival and Severity of InjurySemantic proximity Read

Plasma Exosome-derived MicroRNAs as Novel Biomarkers of Traumatic Brain Injury in RatsSemantic proximity Read

Traumatic Brain Injury Dysregulates MicroRNAs to Modulate Cell Signaling in Rat HippocampusSemantic proximity Read

Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injurySemantic proximity Read

Bioinformatic analysis of brain-specific miRNAs for identification of candidate traumatic brain injury blood biomarkersSemantic proximity Read

Discovery of Novel Long Non-Coding RNAs with potential role in zebrafish brain regenerationSemantic proximity Read

Gene expression changes in lymphocytes and monocytes from patients with traumatic brain injury: A prospective case-control studySemantic proximity Read

Identifying the regulatory network of microRNAs and mRNAs to clarify molecular mechanisms in stroke by bioinformatics analysisSemantic proximity Read

MicroRNA sequencing of rat hippocampus and human biofluids identifies acute, chronic, focal and diffuse traumatic brain injuriesSemantic proximity Read