Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The double life of cardiac mesenchymal cells: Epimetabolic sensors and therapeutic assets for heart regeneration.

Pharmacology & therapeutics - 1 Mar 2017

Cencioni Chiara, Atlante Sandra, Savoia Matteo, Martelli Fabio, Farsetti Antonella, Capogrossi Maurizio C, Zeiher Andreas M, Gaetano Carlo, Spallotta Francesco

Abstract excerpt

Organ-specific mesenchymal cells naturally reside in the stroma, where they are exposed to some environmental variables affecting their biology and functions. Risk factors such as diabetes or aging influence their adaptive response. In these cases, permanent epigenetic modifications may be introduced in the cells with important consequences on their local homeostatic activity and therapeutic potential. Numerous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenesis, Genetic
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesenchymal Stem Cells

Share to Myocardium

Share to Pericytes

Share to Regeneration

Share to Risk Factors

Source

Identifiers

PMID: 27742569
DOI: 10.1016/j.pharmthera.2016.10.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The double life of cardiac mesenchymal cells: Epimetabolic sensors and therapeutic assets for heart regeneration.PMID 27742569Read ↗

Use of mesenchymal stem cells for therapy of cardiac disease.Semantic proximity Read ↗

Unravelling the Biology of Adult Cardiac Stem Cell-Derived Exosomes to Foster Endogenous Cardiac Regeneration and RepairSemantic proximity Read ↗

Mesenchymal Stem Cells and Their Derived Products in Ageing and DiseasesSemantic proximity Read ↗

Origins of Cardiac FibroblastsSemantic proximity Read ↗

Adult stem cell niches for tissue homeostasisSemantic proximity Read ↗

Diverse origins and activation of fibroblasts in cardiac fibrosisSemantic proximity Read ↗

Cardiomyocyte—Endothelial Cell Interactions in Cardiac Remodeling and RegenerationSemantic proximity Read ↗

Changing landscape of hematopoietic and mesenchymal cells and their interactions during aging and in age-related skeletal pathologiesSemantic proximity Read ↗

Reawakening the Intrinsic Cardiac Regenerative Potential: Molecular Strategies to Boost Dedifferentiation and Proliferation of Endogenous CardiomyocytesSemantic proximity Read ↗

Mesenchymal Stem Cells and the Treatment of Conditions and Diseases: The Less Glittering Side of a Conspicuous Stem Cell for Basic ResearchSemantic proximity Read ↗

The Dynamic Role of Cardiac Fibroblasts in Development and DiseaseSemantic proximity Read ↗

Adipose tissue-derived stem cells: the friendly side of a classic cardiovascular foe.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.