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Detection of EGFR gene with a droplet digital PCR chip integrating a double-layer glass reservoir.

Analytical biochemistry - 1 Nov 2022

Yuan Haojun, Gao Wanlei, Yin Jiawen, Chen Kai, Mu Ying, Jin Qinghui, Jia Chunping, Cong Hui, Yu Jiancheng, Zhao Jianlong

Abstract excerpt

The lack of reliable and practical method for detecting rare hot mutation of epidermal growth factor receptor (EGFR) in circulating tumor DNA (ctDNA) for lung cancer has remained a challenge for general clinical application due to excess wild type DNA in clinical samples. In this study, we developed a droplet digital PCR (ddPCR) platform, integrating a PDMS chip and double-layer glass reservoir. The duplex...

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Identifiers

PMID: 36055398
DOI: 10.1016/j.ab.2022.114877

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